The Texan appeared in a losing effort for Fulham.
Dempsey's Fulham side eventually lost 2-1 in extra time, with Diego Forlan hitting the brace for the Spanish side.
The former New England Revolution forward won several free kicks and provided an energetic option in attack, but couldn't help Fulham find the go-ahead goal.
The winning goal ricocheted off the legs of Fulham defender Brede Hangeland. Though he suits up internationally for Norway, Hangeland was born in Houston, Texas, and turned down American citizenship at the age of 18.
Previously, Jovan Kirovski earned a Champions League metal with Borussia Dortmund in 1997, but didn't see any minutes in the final match. DaMarcus Beasley made it as far as the semifinal round of the Champions League with PSV Eindhoven in 2005.
For more on Americans abroad, visit Goal.com's dedicated page and join Goal.com USA's Facebook fan page!