El Tri will meet the recently-crowned African champion before a busy June featuring World Cup qualifiers and the Confederations Cup.
The match will be El Tri's final tuneup for three June World Cup qualifiers: June 4 at Jamaica, June 7 at Panama, and June 11 vs. Costa Rica. Following the qualifiers, Mexico will head to Brazil for the Confederations Cup.
Nigeria was just crowned champion of the 2013 Africa Cup of Nations, defeating Burkina Faso in the final. Mexico and Nigeria last met in 2007, with the teams playing out a 2-2 draw at Estadio Olimpico Benito Juarez in Chihuahua, Mexico.
Mexico has played 12 matches at Reliant Stadium since 2003, averaging nearly 60,000 fans per appearance.