Manchester United forward Javier Hernandez headlines the 22-man group, while team captain Rafa Marquez misses out with an injury
Captain Rafael Marquez is unavailable due to a hamstring strain, but a pair of 22-year-old midfielders, Pachuca's Hector Herrera and León's Carlos Peña, could pick up their first caps.
Mexico is currently top of Group B in the third round of FIFA World Cup qualifying, having taken maximum points from its four matches so far.
The match against Guyana will be played on Oct. 12 in Houston, Texas, and on Oct. 16, El Tri will host El Salvador in Torreon, Coahuila.
Goalkeeper: Guillermo Ochoa (AC Ajaccio), Alfredo Talavera (Toluca).
Defense: Severo Meza (Monterrey), Israel Jiménez y Jorge Torres (Tigres), Francisco Rodríguez (Stuttgart), Diego Reyes (América), Héctor Moreno (Espanyol), Hiram Mier (Monterrey), Adrián Aldrete (América).
Midfield: Elías Hernández (Tigres), Javier Aquino and Gerardo Torrado (Cruz Azul), Carlos Peña (León), Jorge Enríquez (Chivas), Héctor Herrera (Pachuca), Andrés Guardado (Valencia), Ángel Reyna (Monterrey).
Attack: Oribe Peralta (Santos Laguna), Antonio 'Sinha' Naelson (Toluca), Javier 'Chicharito' Hernández (Manchester United), Aldo de Nigris (Monterrey).
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