A London derby between two Tottenham and West Ham looking to avoid any danger of relegation.
West Ham has beaten Tottenham twice this season and could do with a hat trick of wins over its London rival to appease disgruntled fans.
Manager Sam Allardyce again attracted the ire of West Ham's supporters during a 1-0 Premier League defeat at West Brom last weekend.
Saido Berahino scored the only goal of the game as the Upton Park outfit was consigned to a fourth consecutive loss, prompting some traveling fans to call for the former Newcastle United boss to be sacked.
The experienced Allardyce took the criticism on the chin, stating that it was "part of the job", but with his side five points above the relegation zone, he will be eager to secure at least a draw in its last home game of the season against Tim Sherwood's side on Saturday.
While relegation looks highly unlikely for West Ham, if the club can stop the rot in this weekend's derby then it will be all-but assured of safety.
West Ham has happy memories of its clashes with Tottenham this season, having won 3-0 at White Hart Lane in the top flight back in October and then 2-1 at the same ground in the League Cup in December.
Under-fire manager Allardyce would revel in another victory over a side that looks set to be playing in the UEFA Europa League again next season.
He said: "It would be absolutely fantastic to beat them at home, having beaten them in the Capital One Cup and in the league. At this moment in time, our concerns are: one, we were one of the best clean sheets in the league eight or nine games ago and we haven't kept one since then."
Ajax coach Frank de Boer claimed this week that he is a target for Tottenham, with head coach Sherwood widely expected to be relieved of his duties at the end of the season.
Sherwood has spoken of his disappointment at the continued speculation over his future, but vowed to carry on regardless and he will fancy his chances of heaping more misery on West Ham as Tottenham is in fine form.
A 1-0 win at Stoke City last time out made it three wins from the last four Premier League games and the team is now just three points behind fifth-placed Everton.
Sherwood will be unable to call upon Andros Townsend after the England winger sustained an ankle injury that will rule him out of the FIFA World Cup, but Jan Vertonghen and Etienne Capoue could return.
On-loan striker Marco Borriello (calf) is West Ham's only absentee.