Sam Allardyce's side has readjusted to life in the Premier League well, but faces the north London outfit in its first clash against one of the division's leading sides this term.
Demel, Tomkins, Collins, Taylor
Vaz Te, Nolan, Jarvis
Jenkinson, Mertesacker, Vermaelen, Gibbs
Ramsey, Cazorla, Podolski
Sam Allardyce has few injury concerns ahead of Arsenal's visit to Upton Park. Winston Reid was substituted in the first half of the Hammers' win over QPR after taking a heavy blow to the head from teammate Jussi Jaaskelainen, and James Tomkins will come in if the New Zealander is unfit to play.
Andy Carroll made a 20-minute cameo in that game and after returning to full training, and could be rewarded with a second start for the Hammers.
Joey O'Brien was also forced off at Loftus Road, with Matt Taylor waiting in the wings to return in the left back spot. The east Londoners' only other injury concern is Jack Collison (knee), who is yet to feature so far this term.
Vito Mannone is likely to keep his place in goal for the visitors with Wojciech Szczesny (ankle) and Lukasz Fabianski (shoulder) still sidelined. Per Mertesacker has missed the last two games through illness and will face a late test ahead of this tie, but should be in line for a recall with Carroll likely to play.
Francis Coquelin appeared in the Gunners' midfield in midweek against Olympiakos and may also retain his place, with Abou Diaby (thigh) set to be missing until after the international break. Bacary Sagna (leg), Jack Wilshere (ankle) and Emmanuel Frimpong (knee) are all nearing first-team comebacks but are highly unlikely to feature at Upton Park.
|DID YOU KNOW?|
- West Ham has won both of its games against London opposition so far this term, defeating Fulham 3-0 and QPR 2-1.
- The Hammers have picked up more bookings (15) than any other side in the Premier League so far this season.
- Carlton Cole (pictured right) is two appearances away from the 300th of his career.
- West Ham has not beaten its north London opponents since April 2007, losing seven of its nine meetings since.
- Arsenal lost five of its 10 domestic games after Champions League ties last season, also going down to defeat in each of its away games following continental competition.
- Arsene Wenger is into his 17th year as the Gunners' manager after celebrating the 16th anniversary of his appointment last Sunday.
- If Arsenal is victorious, it would represent the 350th win of Wenger's reign.
- The Gunners have the joint-best (with Chelsea) defensive record on their travels in the Premier League, having conceded just once on the road so far this term.