Honda is set to join AC Milan in January but will hope to guide his current side to a Europa League place by avoiding defeat in the Czech Republic.
Bayern Munich and Manchester City have proved to be the dominant forces in Group D and meet at the Allianz Arena with their passages to the knockout stages secured since matchday four.
Plzen is hoping to extend its European campaign after Christmas for the third successive season but the odds of claiming a place in the last 32 of the Europa League are in CSKA's favor.
Leonid Slutsky's team claimed a 3-2 victory when the teams met in Moscow on matchday two - the only three points either side have claimed in the pool.
Therefore, Plzen must win with a superior scoreline to snatch the Europa League berth. If it wins 3-2, CSKA’s European season will be spared by virtue of its superior goal difference.
The Czech champions have lost both their home matches without scoring in the group, with Bayern Munich claiming a 1-0 win after three second-half goals had done the job for Manchester City, but it was a different story for Pavel Vrba's men in previous seasons.
They won 10 of their 11 preceding fixtures at the Doosan Arena in UEFA competitions, while CSKA's away form on the continent has taken a similar nosedive.
Before comprehensive 3-0 and 5-2 reverses at the respective hands of Bayern and City, they had only lost two of their previous 11 away trips – a run that played a part in four consecutive successful group campaigns across the UEFA Cup, Champions League and Europa League.
Keisuke Honda scored for CSKA in their win over Plzen in September and this game will be the Japan playmaker's last on the Russian club's books as he is set to join AC Milan on a free transfer in January.
The match also marks the end of an era for Vrba, who will leave Plzen on December 15 to take charge of the Czech national team.
Vrba took charge of Plzen in 2008, winning the club's first piece silverware - the Czech cup - in his second season, before going on to claim the 2011 and 2013 Gambrinus Liga titles.