The hosts have not suffered a defeat in their last 12 games as they continued their reign in South America by seeing off their guests in Montevideo.
A magnificent performance by Luis Suarez earned Uruguay a 4-0 victory over a weakened Chile side in the Centenario in Friday's World Cup qualifying fixture.
The Liverpool star scored four goals, two in the space of three minutes late in the first half, as Oscar Tabarez's men remain top of the table in Conmebol qualifying with seven points.
On Wednesday, Chile coach Claudio Borghi sent home Arturo Vidal, Jorge Valdivia, Jean Beausejour, Gonzalo Jara and Carlos Carmona for missing curfew, but the players may have not made a difference after a stunning display by Suarez.
With Alexis Sanchez on the bench, Chile suffered dearly as the home side terrorized its defense every couple of minutes.
Suarez should have put the hosts up eight minutes in with a lovely run on the right side of the box, but his touch towards the front post was saved well by Claudio Bravo, who denied Edinson Cavani from close minutes later.
More chances came for the two-time World Cup winners as Suarez struck the post from inside the box, then hit the crossbar from a free kick from around 30 yards just three minutes later.
The fans were finally awarded a goal as Suarez, after several close calls, punished Borghi's men with a stunning strike minutes before the break. From 25 yards out, off a pass from Arevalo Rios near midfield, the former Nacional man drilled a perfect shot into the right corner of the goal for the advantage.
Two minutes later, Suarez doubled the score after Bravo fumbled the ball at the top of the box, resulting in a lobbed shot from Cavani that was cleared off the line by Pablo Contreras. Suarez jumped into the air in front of goal to fight for the 50-50 ball with Waldo Ponce, and the strength of the Uruguayan sent the ball off his shoulder and into the right side of the net.
Chile's night worsened in the second half when Suarez again found the net, heading home a cross from Martin Caceres with just over 20 minutes to go.
Then, just six minutes later, Suarez volleyed home his and his side's fourth from the top of the box into the right corner to cap off his best performance in the national jersey.
With the win, Uruguay remains undefeated in qualifying over three games and will play Italy on Tuesday in a friendly. Chile, which has three points from three matches, will be back in action on Tuesday against Paraguay.