The north London outfit will hope to prove too strong for the visiting Latics and clinch an important three points to stay above both Everton and Arsenal in fourth.
Walker, Gallas, Caulker, Vertonghen
Lennon, Sigurdsson, Sandro, Bale
Ramis, Caldwell, Figueroa
Boyce, McArthur, McCarthy, Beausejour
Kone, Di Santo
Andre Villas-Boas will again be without first-choice defenders Benoit Assou-Ekotto (knee) and Younes Kaboul (knee) with Jan Vertonghen looking likely to deputize at left-back once more, and Steven Caulker set to partner William Gallas in central defense.
England midfielder Scott Parker and Mousa Dembele provide notable midfield absentees for the hosts, while Jermain Defoe's sensational recent form up front is likely to keep Emmanuel Adebayor out of the starting lineup despite the Togolese forward recovering from a back problem.
Brad Friedel is expected to start, but is by no means guaranteed his place after Hugo Lloris' impressive midweek display against Norwich.
Meanwhile, the visitors are likely to revert to a similar lineup that saw them conquer West Ham last weekend in the wake of their League Cup humbling against Bradford.
Robert Martinez is still unable to pick Antolin Alcaraz (groin) and Albert Crusat (knee), but Ryo Miyaichi's return from injury could see him push for a place on the Wigan bench. Arouna Kone's three goals so far this campaign make him odds on to partner Franco Di Santo - who recently earned his maiden call-up to the Argentina squad.
|DID YOU KNOW?|
- All of Tottenham striker Jermain Defoe's five Premier League goals this season have come from inside the box, with two coming from the England striker's weaker left foot. The diminutive forward also has 11 goals in 10 games against Wigan.
- Ahead of the game, Andre Villas-Boas' Premier League win ratio stands at exactly 50 percent - with 63 points amassed from 36 games and a goal difference of +19.
- Three years ago, Tottenham thrashed Wigan 9-1 at White Hart Lane, with Defoe grabbing five. Of the team that started that game for Spurs, only Defoe, Michael Dawson and Aaron Lennon are in contention to start this weekend's encounter.
- The Latics have won just once in four outings at White Hart Lane in the Premier League and twice in nine league games against Spurs.
- Franco Di Santo (pictured) was Wigan's top scorer last season with only seven goals. He has already notched three goals so far this term.
- Wigan has conceded 16 goals in its nine games this season, including five headed goals and three converted penalties - both being the highest out of any Premier League side.