Roberto Soldado's controversial penalty separated the two sides last time out at White Hart Lane, with Andre Villas-Boas likely to make several changes to his starting XI.
Andre Villas-Boas' charges secured a 1-0 triumph over Hull in Sunday's Premier League encounter, and Spurs will once again welcome Steve Bruce's side to White Hart Lane on Wednesday.
Tottenham's weekend victory came in debatable circumstances, as referee Michael Oliver awarded a penalty against Ahmed Elmohamady for handball.
The decision appeared a harsh one, with the Egyptian seemingly unintentionally using his arm to block Jan Vertonghen's cross.
Spain international Roberto Soldado duly converted the spot kick - his third from 12 yards already this season - as Spurs secured back-to-back top-flight victories, much to the chagrin of Bruce.
The fixture with Hull is the home side's third in the space of just seven days, meaning Villas-Boas could rotate his squad with the likes of Erik Lamela coming into contention.
The former Roma midfielder has yet to start a Premier League game for the club, and Villas-Boas admits he is looking for the 21-year-old to stake his claim for a starting spot.
"With Erik it was a little bit more difficult but we have given him massive, massive help and his family arrived this week," he said. "He knows he isn't producing half of what he can produce but he understands the situation now is that he has to compete for his place."
The game is likely to come too soon for Etienne Capoue, despite his return to training from an ankle injury, while Danny Rose is out with a similar problem, but Andros Townsend is not expected to be sidelined after he fell into a photographer's pit on Sunday, injuring his wrist in the process.
Hull, meanwhile, has been in good form upon its return to the top flight, with Bruce's side taking 11 points from nine games, and moving to 10th place in the Premier League.
Sunday's reverse means the team has gone three games without a league victory, including losses in the last two matches.
Hull heads into the match with an extensive injury list that includes goalkeeper Allan McGregor [thigh], defenders James Chester [hamstring] and Abdoulaye Faye [knock] and forwards Sone Aluko [calf] and Danny Graham [hamstring].
Tottenham defeated Aston Villa in the previous stage, while Hull has seen off challenges from Leyton Orient and Huddersfield Town to make round four.