Three first-half goals left Tigres past Pachuca into the semifinals, where the club will meet Queretaro.
First-half goals from Manuel Viniegra, Lucas Lobos and Damian Alvarez sealed the win. Hector Herrera was sent off for the visitors in the 61st minute.
Tigres entered the second leg with a one-goal lead after knocking off Pachuca 1-0 last weekend. The club moves on to face Queretaro in the semis.
Viniegra started the scoring in the 11th minute when he headed in a corner. Lobos scored in the 26th after beating two defenders for a low strike, while Alvarez beat the goalkeeper to tap the ball into an empty net in 35th.