Jurgen Klopp's side missed out on the chance to move four points clear of third-placed Schalke after drawing with its arch rival on Tuesday.
Borussia Dortmund continues its quest for second place in the Bundesliga against Stuttgart on Saturday.
Pep Guardiola's Bayern Munich made certain of its 24th league title with a 3-1 victory at Hertha Berlin on Tuesday as the club moved 25 points clear of Dortmund in second.
Jurgen Klopp's men were held to a goalless draw in the Revierderby at Signal Iduna Park on the same night as they missed the chance to move four points clear of the visiting side in the race for the runner-up spot.
BVB faces a Stuttgart side buoyed by the recent appointment of Huub Stevens, with the Dutchman having overseen an end to the club's 10-match winless run in the league with last Saturday's 1-0 victory over fellow struggler Hamburg.
However, the team failed to follow that up when it lost 2-0 at Nuremberg in midweek and missed a chance to climb out of the relegation zone.
Stevens is at least boosted by the inclusion of attacker Martin Harnik, who returned from suspension against Nurnberg and should once again play a part.
Klopp's men come into the game boasting an impressive recent away record, having won on four of their last five Bundesliga away trips.