Nigel Adkins' side will be desperate to gain its first points of the Premier League season against Sir Alex Ferguson's men, who have lost three of their last four away games.
Clyne, Hooiveld, Fonte, Fox
Davis, Schneiderlin, Lallana
Rodriguez, Lambert, Lee
Rafael, Carrick, Vidic, Evra
Valencia, Kagawa, Young
Southampton could well revert to the 4-3-3 system which served it well against champion Manchester City on the opening matchday, with Championship Player of the Year Rickie Lambert expected to lead the line, supported by Jay Rodriguez and Tadanari Lee out wide.
Guly Do Prado is expected to be left out of the squad following his off-the-field indiscretions. New signings Maya Yoshida and Gaston Ramirez are unlikely to start, but could well feature in the Saints squad.
Manchester United is expected to name the same side which beat Fulham 3-2 last Saturday. Jonny Evans made a full comeback in the reserves midweek but is unlikely to be fit enough to return to first team duties, meaning Michael Carrick will continue alongside Nemanja Vidic at center back.
With Wayne Rooney sidelined for the next month, Robin van Persie will almost certainly start at the head of a four-pronged forward line, with Antonio Valencia, Ashley Young and Shinji Kagawa forming the attacking fulcrum of the midfield.
|DID YOU KNOW?|
- Southampton boasts an impressive recent home record in league soccer, winning 27 of its last 36 games across three divisions.
- The Saints inflicted one of Manchester United's heaviest-ever Premier League defeats in October 1996, when an Egil Ostenstad hat trick fired them to a 6-3 win.
- Fullback Nathaniel Clyne (pictured right) was long linked with a move to Manchester United before ultimately signing for Nigel Adkins' side over the summer.
- Southampton has won 38 percent of matches at home against the Red Devils in the top flight. Only Chelsea and Arsenal boast better records.
- Manchester United has lost three of its last four Premier League matches away from home. All four of those games have ended with a 1-0 scoreline.
- The Red Devils have a superb recent record at St Mary's, however, winning on each of their last four visits.
- Robin van Persie was sent off on his only appearance at the ground during Saints' 1-1 draw with Arsenal back in 2005.
- Sir Alex Ferguson's side has allowed its opponents 13 shots at goal so this season - more than any other side in the top flight.