Confident as ever in claiming crosses and keeping possession despite Liverpool's pressing but helpless for all three goals.
Prevented a near-certain goal with an early interception but a slightly heavy touch then put Suarez through for the opener - and he was outsmarted by the Uruguayan for the stoppage-time penalty. Suarez and Sturridge were just a little too good for him.
His crossing varied in consistency but a very respectable performance from the young defender, standing up to the Reds' attacking threats with impressive maturity. Deservedly keeping a fellow England hopeful, Nathaniel Clyne, out of the starting XI.
Showed some moments of nervousness in the early stages, perhaps feeling the spotlight after his England call-up, but soon came to his senses and started probing fearlessly down the left flank.
Back in the first team after injury and looked, understandably, somewhat rusty. Despite some moments of class, the Croatian suffered when isolated against the likes of Suarez and Sturridge and his mistake let Sterling in for the second.
Made his presence felt at both ends in a typically industrious first half but was the first man sacrificed at half-time as Mauricio Pochettino looked to add more attacking bite with Ramirez.
Sparkled during the first half in yet another reminder of his international quality. Unlucky to see his shot come back off the wrong side of the post. With the balance of the side changed at the break, though, his influenced dimmed.
Occasionally overeager in the tackle but willing and confident. Perhaps could have done more to keep an eye on Sterling's run for the second goal. Taken off for Wanyama.
Forceful in the challenge but unable to totally dominate the visitors' midfield. Flicked a difficult first-half chance well over and was unable to compensate for the half-time departure of Davis.
So impressive in his flexibility, the England international flitted from the No.9 position to both flanks as necessary in a constantly testing three-pronged attack. Drew a great save out of Mignolet, but dropped off after the break.
No clear-cut chances with which to test his finishing but excellent in build-up, his magnificent chested pass setting up Lallana to tap against the post. Great movement around the final third.
Made an excellent first-half stop from Rodriguez to maintain his side’s advantage in a very solid day's work.
Occasionally confused by the flexible Saints attack but largely a fine performance from the Dane, particularly in the second half.
Unable to provide a great deal of width on his less-favoured left flank and, with no protection from a wide midfielder, allowed Chambers plenty of room coming forward.
Strong in the tackle, the centre-back shut down more Southampton attacks than got past him and contained his opponents particularly well after the break.
Tested by the likes of Lallana down the Liverpool right but generally stood up well to the challenge.
Planted at the base of a midfield diamond, the Liverpool skipper was not the ideal man to squeeze the Saints' flexible forward line but improved in the second half when the formation tightened around him.
A calm presence in the midfield from another of Roy Hodgson's calls-up, putting in a quiet shift. His forward raids resulted in some wayward finishing, however.
Brought in to shore up the midfield and, after some misplaced passes in the first half, the Welshman was a very steady presence.
Withdrawn early in the second half for Sterling after an iffy performance. Showed fleeting glimpses of his incisive passing but not enough.
Did not dominate as completely as he can but demonstrated the value of a world-class striker with his assured first-half finish on his 100th Premier League appearance. Later set up Sterling and continued to torment a tiring defence, winning the stoppage-time penalty.
An unselfish threat as he teamed up with Suarez to cause problems to the hosts’ defence but was unable continue his scoring streak, instead having to settle for a joint-record with Ruud van Nistelrooy for successive league games scored in. Substituted for Aspas late on.
Made his return from injury off the bench and soon picked up a deserved yellow for a clattering challenge on Suarez. Not the man Southampton needed to change the game.
Bright in spots after being surprisingly brought on for Davis at half-time but his introduction changed Southampton's structure for the worse and he could offer no real penetration.
Came on for Lambert in the second half but, even by that point, the game felt gone and the young striker was unable to make a difference.