A sparkling performance from the Saints captain inspired Mauricio Pochettino's side to a rampant home win over Steve Bruce's Tigers.
Rickie Lambert and Adam Lallana were both on the score sheet in the first half at St Mary's Stadium as Mauricio Pochettino's men made it four top-flight wins in a row at home, while Morgan Schneiderlin and Steven Davis also made sure that Yannick Sagbo's second half goal was only a consolation.
The home side went ahead early on, with Schneiderlin taking advantage of poor defending in the Hull ranks to head home Lambert's knock down.
Lallana was instrumental in the second, as he looked to get onto the end of a Lambert pass, only for the onrushing Steve Harper to take him down. Lambert then emphatically converted the penalty to maintain his 100 percent record from the spot for Southampton from 33 attempts.
Southampton's third came after 36 minutes, courtesy of Lallana himself. The 25-year-old jinked his way into the area before calmly slotting the ball past Harper from a tight angle.
Sagbo pulled a goal back for Hull early in the second half following an error from Victor Wanyama. However, any hopes of a comeback had all but disappeared by the time Davis hit a low drive past Harper in the closing stages.