A 3-1 win in Abidjan put the Elephants in control of the tie last month but Papiss Cisse's late strike gave Alain Giresse's side a glimmer of hope.
Alain Giresse saw his men succumb to a 3-1 loss in Abidjan last month but remains confident in their ability to overturn the deficit when the two sides meet again for the second leg in Casablanca on Saturday.
Goals from Didier Drogba, Salomon Kalou and a Ludovic Sane own goal put Cote d'Ivoire on the verge of a third consecutive finals appearance, but Papiss Cisse's late consolation has given Senegal a glimmer of hope.
The fact that the match is being played in Morocco is likely to make Senegal's task even harder, with the change of venue introduced as punishment for the rioting that took place when the two went head-to-head last year in an Africa Cup of Nations qualifier.
Cote d'Ivoire has only lost one competitive game in 2013 - against Nigeria in the AFCON quarterfinal - and went through its whole qualifying campaign unbeaten.
The team will be without midfielders Cheikh Tiote and Geoffroy Serey Die through suspension, while Boka Arthur (groin) and Siaka Tiene (hamstring) are both unavailable to coach Sabri Lamouchi.
Senegal has only lost one of its last six matches under Giresse, but since the team's stadium ban it has won just one game when it has been the nominated home team.
That victory, which came against Uganda in Marrakech, helped secure the team's place in the playoffs and kept alive its hopes of making a second World Cup finals in the country's history, and first since 2002.
Senegal has no new injury worries but will be without Demba Ba after he was left out by Giresse.