Huub Stevens' side currently sits at the top of its group and knows three points will see it progress to the knockout stages of the Champions League.
Uchida, Howedes, K Papadopoulos, Fuchs
Farfan, Holtby, Draxler
Torosidis, Manolas, Siovas, Holebas
Maniatis, Fejsa, Greco
Fuster, Mitroglou, Abdoun
The big news for Schalke is that it will be able to welcome back Atsuto Uchida at right back. The Japanese star will either replace Kyriakos Papadopoulos or Joel Matip, with Benedikt Howedes shifting in-field, having played as a fullback during the weekend's 2-0 loss to Bayer Leverkusen.
Elsewhere, the hosts have a near-full-strength squad from which to pick the team, with Julian Draxler having recovered and returned after breaking his arm in the home draw with Montpellier.
Meanwhile, Olympiakos can be expected to make a couple of changes from the side that beat Kerkyra 2-0 in Athens on Saturday. Tassos Papazogolou has not traveled with the rest of the squad, and should be replaced by Kostan Manolas.
Giannis Maniatis could return in midfield in the place of Ariel Ibagaza, while coach Leonardo Jardim will have to choose between Rafik Djebbour and Kostas Mitroglou, but could opt for the latter after his recent run of good form in both Greece and Europe.
|DID YOU KNOW?|
- Schalke striker Klaas-Jan Huntelaar (pictured, right) is the only man to have scored on every Champions League group stage matchday so far this season.
- Kyriakos Papadopoulos started his career at Olympiakos, and became the youngest player in Greek Super League history when he made his debut in December 2007 at the age of 15.
- The Gelsenkirchen outfit has only lost two of its last 13 Champions League matches at the Veltins Arena.
- Olympiakos produced an extraordinary comeback to claim a dramatic 3-1 Champions League victory over Werder Bremen at the Weserstadion, back in 2007-08.
- The Athenians also clashed with a Ruhr club last season, losing 1-0 to Borussia Dortmund when they traveled to Germany.
- Left back Jose Holebas was born in Germany, but represents Greece at international level.