The Premier League club sits three points behind the German opponent, which has yet to concede a goal in the Champions League this season.Chelsea heads to Germany to face Schalke on Tuesday hoping to pull itself level on points with the Champions League Group E leader.
The Bundesliga side has made a superb start to its continental campaign, picking up a 3-0 home win over Steaua Bucharest on matchday one, and a 1-0 victory at Basel a fortnight later.
Chelsea, meanwhile, bounced back from a 2-1 opening-game defeat to the Swiss champion in the best possible way last time out - cruising to a 4-0 win in Romania.
That loss against Basel in September is Chelsea's last defeat in any competition, with Jose Mourinho's men currently second in the Premier League following a 4-1 win over Cardiff City on Saturday.
Schalke's domestic campaign has faltered, however, with Jens Keller's men picking up just four victories from their opening nine fixtures, although they head into this clash off the back of a 3-2 win at Eintracht Braunschweig on Saturday in which they were forced to come from behind twice.
The sides have met at this stage of the Champions League on one previous occasion - in 2007 - when Chelsea came away with a point from a goalless draw at the Veltins-Arena, having beaten the German side 2-0 at Stamford Bridge.
Both eventually qualified from that group, with Chelsea going on to lose the final on penalties to Manchester United.
Schalke will be looking to its top domestic goalscorer Adam Szalai to find his shooting boots in Europe, while Julian Draxler will aim to maintain his record of having scored in both matches in the group stages so far.
But the Bundesliga's fifth-placed side has a lengthy injury list to contend with, including striker Klaas-Jan Huntelaar, who is set to miss three to four months with a knee injury that will require surgery.
Midfielder Marco Hoger was also forced off in the weekend win with a knee injury and is now a major doubt.
For Chelsea, Ashley Cole is a fitness concern after missing England's final two World Cup qualifiers and his club's win at the weekend with a rib injury, while Andre Schurrle was also absent for the Cardiff match due to a muscle problem in his leg.
Victory by one goal would be enough to send Chelsea above Schalke in the group.