A second-half goal from Sidney Sam condoned more misery on Schalke who remain in the bottom two.
The game started with the home side in the ascendancy but both teams struggling to create clear-cut chances. However the game sprung to life on 22 minutes when die Koenigsblauen came within touching distance of opening the scoring.
Great play down the right by Jefferson Farfan saw the Peruvian whip an excellent ball into the box. Klaus Jan Huntelaar was on hand six yards out but the strike had to watch on in agony as his header smashed back off the bar.
One minute later it was Leverkusen's turn to come close to scoring the first of the game when Arturo Vidal missed a glorious chance. Daniel Schwaab curls in a wonderful ball towards the unmarked Patrick Helmes and Vidal. The Chilean midfielder got his head to the ball but failed to divert the ball on target.
In the 27th minute it was the home side's turn to once again come within whiskers of taking the lead. Japanese right-back Atsuto Uchida made a storming run forward and surprised Rene Adler with a near post effort from 20 yards. The German number two managed to get his hand to the ball and claw it away from danger.
Die Werkself threatened again on 42 minutes when some great play by Patrick Helmes saw the ball fall to the unmarked Tranquillo Barnetta 15 yards out who saw his powerful effort saved well by Manuel Neuer.
Leverkusen came close again one minute later when Erin Derdiyok's 30 yard free-kick stung the palms of the German 'keeper who managed to turn the ball around the post for a corner.
Die Knappen started the second half strongly and on 47 minutes Huntelaar once again hit the woodwork, this time the post. Again it was Farfan who provided the killer cross and Adler was left helpless and would have been relieved to see the ball rebound of the post and to safety.
Yet it was the away side who scored what would prove to be the only goal of the game on 66 minutes. An excellent through-ball from Lars Bender allowed Sidney Sam to use his raw pace to storm past the likes of Metzelder and Hoewedes. The young German winger showed great compusure to slip the ball past Neuer and into the net for his second goal of the season.
Despite Schalke's best efforts Leverkusen comfortably held out to win yet another game away from home. Schalke now head to Israel on Tuesday night for their Champions League game versus Hapoel Tel Aviv. Leverkusen host Freddy Adu's Aris Thessaloniki on Thursday in the Europa League.
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