Goals from Fernando Torres and Victor Moses in the first leg allow Rafa Benitez's men a bit of breathing space as they make the long trip to the Russian capital.
Kaleshin, Navas, Sharonov, Ansaldi
Kasaev, Eremenko, Karadeniz
Azpilicueta, Ivanovic, Terry, Ake
Moses, Oscar, Hazard
Vladimir Dyadyun will compete for a place up front with Salomon Rondon for the host, which has no injury concerns to speak of.
Cesar Navas, Ivan Marcano and Roman Sharonov will fight for two places in the center of defense. Oleg Kuzmin may replace Gokdeniz Karadeniz on the right-hand side of midfield.
Chelsea faces a potential dilemma at left back, with the injured Ashley Cole's (hamstring) and usual deputy Ryan Bertrand (virus) unfit to travel. Nathan Ake is the club's only other natural left back, though Paulo Ferreira could fill in from his preferred right back position.
Gary Cahill is still a couple of weeks away from returning after undergoing minor arthroscopic surgery to shave the meniscus on the knee he damaged in last month's win against West Ham.
With Demba Ba cup-tied, Fernando Torres will continue up front, having scored twice in the first leg at Stamford Bridge.
David Luiz, Ramires and Juan Mata are likely to be rested after playing three games in less than a week, so John Terry, Frank Lampard and Victor Moses should come into the starting lineup.
|DID YOU KNOW?|
- Chelsea has won all five of its previous games against Russian sides, conceding just twice in the process.
- The Blues beat Spartak Moscow 2-0 on their last visit to the Luzhniki Stadium, in the 2010-11 Champions League group stage.
- John Terry (right) will make his 100th European appearance if he plays in Moscow.
- Rubin's only previous home game against English opponents resulted in a 1-0 win over Tottenham in last season's Europa League.
- However, the Russians' only three defeats in their last 22 European 'home' games have come when hosting their matches in Moscow, as opposed to their Tsentralnyi Stadion in Kazan.
- Having already eliminated Europa League winners Atletico Madrid in the round of 32, Rubin could complete an unlikely double of knocking out the holders of both of last season's European trophies if it overcomes Champions League holder Chelsea.