Cristiano Ronaldo serves the final game of his three-match suspension as Carlo Ancelotti's men go in search of a 15th consecutive home win in all competitions.
Real Madrid will move to the top of La Liga for at least a few hours if it extends its unbeaten run to 26 matches against Elche on Saturday.
Carlo Ancelotti's side is locked on 60 points alongside Barcelona and Atletico at the summit of the Spanish top flight, but sits second behind the Catalan club by virtue of its inferior goal difference.
Madrid plays before either of its great rivals this weekend, though, with Barca visiting Real Sociedad later on Saturday and Atleti traveling to Osasuna on Sunday, meaning it requires just a point at home to Fran Escriba's men to take top spot.
However, the capital club's imperious form of late - not losing a game since their 2-1 Liga reverse at Camp Nou in October - suggests it will pick up a 15th consecutive home victory in all competitions.
Indeed, the only team to avoid defeat in 18 matches at the Bernabeu in La Liga, the Champions League and the Copa del Rey this term is Atleti, which came away with a 1-0 league win in September.
Elche can take some heart from the fact Cristiano Ronaldo will be absent this weekend, with the Portugal star serving the last of his three-game ban after his sending off at Athletic Bilbao earlier in the month.
Ronaldo netted twice in Madrid's 2-1 victory at the Estadio Manuel Martinez Valero in September - including a controversial 96th-minute winning penalty - and is La Liga's top scorer this season, with 22 goals in 21 appearances.
Los Blancos have seemingly not missed the former Manchester United man, however, as they have put seven goals past Villarreal and Getafe in the two Liga games since his dismissal at San Mames.
Jese Rodriguez has replaced Ronaldo on the left and has also filled the Portuguese's boots capably, with a goal in each of his last three games.
A 3-0 win at Getafe last time out took Ancelotti's men to 101 goals in 38 games in all competitions this season and, given Elche's poor record on the road, that total looks set to grow this weekend.
Escriba's team, which sist 13th in the table, has won just two of its 11 away Liga matches this season, conceding 23 goals in the process.