Goals from Ricky Lambert, Jason Puncheon and an own goal from Anton Ferdinand left the QPR manager worried after a disappointing 3-1 defeat
An impressive first 45 minutes from the Saints left QPR chasing a two-goal deficit going into the second half, as a header from Lambert and a sweet strike from Puncheon left QPR in a sorry state at the halftime break.
Rangers were unable to mount a comeback in the second half, despite an early goal from Junior Hoilett, as Southampton continued to cause the Londoners more problems and an own goal from Ferdinand ended their hopes of picking up a first Premier League win of the season.
Southampton started with the better of the action with two chances in the first 10 minutes, Lallana first blazing over after a lovely move and, just minutes later, an in-swinging cross from Puncheon found its way on to the post.
Following slack defensive play from QPR, another chance fell Southampton's way. From a corner, Lambert was left unmarked at the back post but the 30-year-old was unable to direct his header past Julio Cesar as the Brazilian tipped it wide.
From the ensuing corner, however, Southampton found the breakthrough. QPR were unable to clear their lines and the ball found its way to Cork in the area - a shot from the midfielder was skewed wide but Puncheon was there at the back post for what seemed like a routine tap-in. Jose Bosingwa thwarted the winger with a goalline clearance but, atoning for his earlier miss, Lambert was there to head home the rebound.
With the end of the first half already in sight, Puncheon added further to QPR's dismay when, following excellent work from Nathaniel Clyne down the right, the winger fired home with a powerful effort from the top of the box, with QPR pressure non-existant.
Predictably, QPR were booed off at halftime and Hughes acted accordingly, bringing on striker Jamie Mackie for defensive midfielder Alejandro Faurlin.
It was just minutes before an excellent Taarabt cross forced QPR back into the game. The midfielder picked up the ball on the left wing and delivered a dangerous inswinger. It proved too dangerous for Gazzaniga as he came and found himself nowhere near the ball, leaving Hoilett with a simple header.
Following the goal, Southampton asserted itself on the game once more as QPR's defense looked susceptible. Southampton remained dominant throughout the half with Puncheon causing problems. Chances continued to fall his way but he was unable to capitalize.
With Hughes' side struggling to trouble the away side, Yoshida forced a great save from Cesar in the 75th minute, following yet another troublesome corner.
Southampton's dominance paid off in the 82nd minute as a short corner caught QPR unaware, resulting in a low ball being played across the penalty area that Ferdinand could only divert into his own goal.