Laurent Blanc's men can leap to the top of Ligue 1 with a win on Saturday, although back-to-back victories suggests the visitors are in form.
The defending champion is yet to lose so far this season, although it produced a below-par display in a slender 1-0 victory at Valenciennes on Wednesday, with Edinson Cavani scoring his third goal for the club since joining from Napoli.
That victory made it 18 games without defeat for PSG in Ligue 1, a run that stretches back to the beginning of March, but the Parisiens will need to be in good form to maintain that streak against a Toulouse outfit that has experienced a recent upturn in fortunes.
The capital club can overtake Monaco, which travels to Reims on Sunday, with a victory, and it will need no further incentive ahead of the visit of Alain Casanova's men.
Center back and captain Thiago Silva (thigh) is head coach Laurent Blanc's main absentee, but there is concern over the fitness of fellow defender Alex, who has also struggled with a thigh injury in the past few weeks and was brought off at halftime against Valenciennes.
Blanc rotated his squad for the game at the Stade du Hainaut, which came just three days after their draw with Monaco, and, with Benfica traveling to the Parc des Princes for a Champions League clash on Wednesday, the former France boss will need to use his squad intelligently.
PSG has an excellent record against Toulouse in recent years, winning the last eight meetings in all competitions between the two sides. Still, Toulouse has turned its fortunes around in the last two games, coming from behind to win 2-1 at Saint-Etienne, before beating Lorient 1-0 on Wednesday.
Toulouse's last win over PSG came in 2009, when it triumphed 1-0 at the Stade Municipal. It will bid to end that drought without the services of striker Eden Ben Basat (hamstring), defender Jean-Daniel Akpa-Akpro (muscle strain) and midfielder Mihai Roman (Achilles).
Still, Casanova's side has been boosted by the form of Danish forward Martin Braithwaite, who has scored in the club's last two games.