A 2-1 reverse to Stade Rennais in November 2012 was the last time les Parisiens were beaten in Ligue 1 at Parc des Princes and they will be confident against Claude Puel's side.
Laurent Blanc's men have not lost a home league game since Nov. 2012 and sit in a commanding position at the top of the table following their 4-0 rout of Lorient last Friday.
PSG is two points clear of nearest challenger Lille, which moved ahead of Monaco in the table after dealing the big-spending principality club its first defeat of the campaign last week.
Despite an underwhelming 1-1 draw with Anderlecht in the Champions League on Tuesday, the defending champion should be confident of cementing its position at the top of the division.
Nice's last victory in the capital came back in 2009, and Claude Puel's side will need to be at its best if it is to replicate that feat on Saturday and overcome a PSG side close to full strength.
Striker Edinson Cavani is the home side's only injury concern due to a thigh problem that kept him out of the game with Anderlecht.
Nice goes into the game on the back of a disappointing 2-1 home defeat to Bordeaux, a result that marked the club's first loss at the new Allianz Riviera stadium.
Goalkeeper David Ospina suffered knee ligament damage in that game and now faces six weeks on the sidelines.
Mouez Hassen, who replaced Ospina against Bordeaux, is also doubtful with a groin problem, meaning Lucas Veronese is likely to take over between the posts.
Dario Cvitanich promises to be the danger man for the Cote d'Azur club after a fine start to the campaign.
The Argentinian has already scored seven league goals this term, with only Cavani and Radamel Falcao finding the net on more occasions, although Cvitanich faces a tough task if he is to add to that tally against a defense that has conceded only seven league goals.