Massimiliano Allegri's side has enjoyed great success against the Rossoblu in recent times but have struggled on the road this season.
The Rossoneri have yet to win in four league games on their travels this season, but do boast a superb record against the Rossoblu, having lost just one of the last 18 meetings between the two sides.
Parma's only victory over Milan in the last 10 years came in March 2010, when a late goal from Valery Bojinov secured a 1-0 win at the Stadio Ennio Tardini.
However, Roberto Donadoni's men will be buoyed by victories in each of their last two home games against Atalanta and Sassuolo.
Parma currently sits 13th in the table, but were unbeaten in four prior to a 3-2 reverse at Hellas Verona last time out.
Milan's last action came in the Champions League as they held Spanish giant Barcelona to a 1-1 draw at San Siro.
Massimiliano Allegri's men have yet to lose in Europe's premier club competition, but their league form has been patchy and they already trail leaders Roma by 13 points.
Philippe Mexes remains suspended for Milan, which must also cope without injured duo Giampaolo Pazzini and Stephan El Shaarawy.
Mattia de Sciglio has returned to training, though, and could make his return from a knee problem, while Brazilian goalkeeper Gabriel will hope to make a second appearance after a fine debut against Udinese last weekend in the absence of Christian Abbiati, whose fitness remains in doubt.
Daniele Galloppa and Gabriel Paletta are still on the sidelines for Parma, but Antonio Mirante is available again following a ban.