U.S. captain Clint Dempsey could make his debut on loan for the Cottagers, who face a Canaries side that has gone five games without a win.
Dempsey, on a two-month loan from the Seattle Sounders, played for Fulham from 2007 to 2012, compiling 52 goals and 18 assists in 184 appearances.
Norwich has not recorded a victory over the Craven Cottage outfit since March 1986, a 2-1 league triumph. The two sides have met on 13 occasions in all competitions since then, with Fulham winning 10 of those encounters.
The last of those Fulham victories came on Boxing Day when Rene Meulensteen's men recorded a crucial three points in their fight against Premier League relegation as strikes from Pajtim Kasami and Scott Parker overturned Gary Hooper's opener.
Meulensteen's side heads into Saturday's showdown at Carrow Road on the back of a morale-boosting 2-1 victory over fellow struggler West Ham on New Year's Day. After falling behind to Mohamed Diame's strike, the hosts bounced back courtesy of goals from Steve Sidwell and Dimitar Berbatov.
Fulham's best FA Cup run came when it reached the 1975 final, losing 2-0 to West Ham, while the club has failed to progress past the fourth round in the past two seasons, with a 4-1 loss to Manchester United ending its hopes last year.
Norwich's recent history in the competition has not been favorable. City failed to go beyond the fifth round since losing 1-0 to Sunderland at the semifinal stage in 1992 and suffered a shock 1-0 defeat to non-league Luton Town in round four in 2013.
Chris Hughton's men have endured a blip in the last month and have failed to record a victory in their last five matches, drawing three and losing twice. A 1-1 draw at Crystal Palace on Wednesday saw Jason Puncheon's penalty cancel out Bradley Johnson's opener.
Norwich will be without midfielder Leroy Fer as he serves a one-match suspension after receiving two yellow cards against Palace, while there are fitness doubts over center back Michael Turner (hamstring) and midfielder Jonny Howson (back).
Fulham has no fresh injury worries with goalkeeper Maarten Stekelenburg (ankle) and defender Brede Hangeland (leg) set to miss out.