Guy Poyet's side recorded a 2-1 win over Alan Pardew's men in October and will be looking for another three points in order to boost its survival hopes.
Gus Poyet's first home game in charge of Sunderland in October resulted in a 2-1 victory over its arch-rival thanks to Fabio Borini's late goal - a win that was its first in the Premier League this season.
It will take even greater confidence from last season's corresponding fixture, which resulted in a memorable 3-0 triumph under Paolo Di Canio - its first victory under the Italian, who was sacked after a winless start to the campaign.
The three points on that April day went a long way to helping Sunderland to top-flight survival last season, which is again thei club's main aim this term.
Wednesday's 1-0 win at home to Stoke City lifted Sunderland out of the relegation zone for the first time since the second week of the season, while Newcastle remains eighth, just behind the race for European spots, after a midweek 0-0 draw at Norwich City.
Adam Johnson scored Sunderland's winner in midweek, taking his tally for 2014 to six goals from seven games.
The winger's red-hot form as led to tentative calls for him to make England's World Cup squad, but Sunderland assistant Charlie Oatway is just happy to have the 26-year-old propelling the Wearsiders up the table.
"No one's under any illusions about his ability," Oatway said. "We've managed to get him firing on all cylinders at the moment, we needed that little bit of a bright spark and thankfully it's him."
Further boosting Sunderland's attacking potency is Argentina international striker Ignacio Scocco, who moved to the Stadium of Light from Internacional on Thursday.
The 28-year-old could be in line for a Sunderland bow in the derby, while Luuk de Jong could make his Newcastle debut after joining on loan from Borussia Monchengladbach.
De Jong's arrival came hot on the heels of Yohan Cabaye's 20 million pound departure to Paris Saint-Germain - with the Frenchman's spot in midfield not immediately filled by the St James' Park recruitment team.
Loic Remy is suspended after head-butting Bradley Johnson in Tuesday's draw at Norwich, while Lee Cattermole could be missing for Sunderland after sitting out the Stoke win with a calf injury - though speculation remains that Mark Hughes is hopeful of bringing the midfielder to the Britannia Stadium.