The Magpies boss continues his stadium ban against a club he played for after headbutting Hull City's David Meyler, while the Eagles continue their battle against relegation.
Pardew played for Palace between 1987 and 1991, helping the club reach the FA Cup final in 1990.
However, the 52-year-old will be unable to attend the game as he serves the second game of a three-match stadium ban enforced for his headbutt on Hull City's David Meyler in the 4-1 win at the KC Stadium earlier this month.
Assistant John Carver will again be in charge and will hope for better fortune this time around after suffering a 1-0 defeat at bottom club Fulham last weekend.
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Newcastle can complete a league double over Palace following a 3-0 success at Selhurst Park back in December and boast a strong record against Tony Pulis' side, having not lost to the Eagles since 1998.
But Newcastle has a number of injury concerns going into this encounter and will again be without top scorer Loic Remy because of a calf injury.
Defenders Mathieu Debuchy [groin] and Davide Santon [illness] are both sidelined, but Hatem Ben Arfa and Sammy Ameobi are available after returning to the squad.
Meanwhile, Palace has issues up front with Dwight Gayle set to miss out because of an ankle injury, while Marouane Chamakh is still out with a hamstring problem.
Defender Danny Gabbidon [knock] and Barry Bannan [illness] both missed the goalless draw with Sunderland last weekend and it remains to be seen whether the pair will recover in time to feature.
Glenn Murray and Cameron Jerome are both in contention to replace Chamakh, but Pulis conceded the Moroccan's absence is a problem for his side.
"Chamakh won't be fit for Saturday. It is a massive blow because he plays that position so, so well," Pulis said.
"He is a good player, can score goals and he can drop into that number 10 position. It is a miss, but we have to get on with it."