The Gelsenkirchen outfit ended their season on a high note with an emphatic victory in the German Cup final.
Julian Draxler scored a brilliant opener in the 18th minute, and Klaas-Jan Huntelaar doubled the advantage four minutes later. Benedikt Howedes powerfully headed home a corner moments before half-time, and Jose Manuel Jurado added a fourth in the 54th minute.
Huntelaar completed his brace on 71 minutes, and die Knappen managed to keep a clean sheet in what was likely to be Manuel Neuer's last game in a Schalke shirt.
Duisburg had a couple opportunities to counterattack in the early stages of the match, but showed naivety in front of goal. With the first real chance of the game, Draxler collected a through ball and volleyed home a superb goal from a yard outside the penalty box. Huntelaar poked home Jefferson Farfan's fine set-up four minutes later, leaving Duisburg with a real mountain to climb.
The 2. Bundesliga side did not give up, and would have deserved a goal before half time. Olcay Sahan was through on goal, but took too long to pull the trigger and sent the ball over the bar. Shortly thereafter, Manuel Schaffler was able to turn and shoot on goal, but his strike went straight into Neuer's arms.
The game effectively ended two minutes before the halftime break when against the run of play, Howedes rose to nod a free header into the net.
In the second half, Jurado was once denied before tucking the the ball into the lower-right corner to make it 4-0, after which the match effectively turned into an exhibition. Duisburg were careless at the back, and their evening was summed up in the play leading to Huntelaar's second goal, which came after Goran Sukalo conceded possession in front of his own net, leaving the Dutchman with an easy finish to put the icing on the cake.
With the result decided, the last minutes of the encounter were played at a slow pace until the final whistle, at which time the visiting fans from Gelsenkrichen roared with applause as their team celebrated.
Schalke's victory marks its fifth-ever DFB Pokal title. The result is doubly advantageous as it grants the winners an automatic spot in the 2011-12 Europa League.