The Partenopei have had a super start to life under the Spaniard and Massimiliano Allegri's depleted squad will need to be at its best to win
The Naples outfit has won all four of its competitive fixtures under the Spaniard, a run which has seen it top Serie A and open its Champions League campaign with a victory over last season's runner up Borussia Dortmund.
Milan, meanwhile, has endured something of a mixed start to 2013-14, posting one defeat, one draw and one loss in its first three league fixtures while proving unconvincing in Europe.
Massimiliano Allegri's men came through a potentially testing Champions League play-off against PSV, but needed an 82nd-minute own goal to make the breakthrough before defeating Celtic 2-0 in the first group game.
However, all three of its victories thus far this season have come at San Siro and it goes into this latest fixture boosted by a 27-year record that points firmly in its favor.
Napoli has not beaten Milan in a league game away from home since April 13, 1986, when an own goal from teenage defender Paolo Maldini and a further strike from one Diego Maradona helped secure a 2-1 win.
That famous victory came in the season prior to Maradona leading Napoli to the Scudetto and Benitez will be keen for his team to lay down a similar marker in terms of its title hopes with a historic win.
His chances of overseeing such a triumph are surely helped by Milan's injury list, which includes Riccardo Montolivo, Stephan El Shaarawy, Kaka (all thigh), Daniele Bonera and Mattia De Sciglio (both knee).
By contrast, Napoli has no injury worries or bans to contend with and should be in fine fettle following a win over 10-man Dortmund on Wednesday.