The two teams will renew pleasantries just 10 months after playing out a 2-2 draw in Houston.
For Mexico head coach Miguel Herrera, the match is extremely important, as it is his only chance to see El Tri in action with a full complement of both Liga MX and foreign-based players ahead of the World Cup squad announcement.
Two players named to the squad who won't participate are Club America's Miguel Layun, and Villarreal's Giovani dos Santos. The former has a dislocated shoulder, while the latter is dealing with a calf problem.
The game will be the second time in 10 months that the sides have met in a friendly on U.S. soil. The teams played out a 2-2 draw in Houston in May 2013.
For Nigeria, Joseph Yobo has been called into the squad for the first time in more than a year, while regulars like Sunday Mba, Brown Ideye, John Ogu, Nnamdi Oduamadi, and Chigozie Agbim all miss out. Nigeria faces Argentina, Iran and Bosnia-Herzegovina in Group F at the World Cup.
The game promises to be well-attended. Ticket sales surpassed 54,000 Friday morning, guaranteeing the match will set a record for the largest soccer crowd in the history of Atlanta.