Sir Alex Ferguson's men enjoy a 15-point lead over their cross-city rivals, but the defending champions will be looking to avenge the 3-2 defeat at the Etihad earlier this season.
Rafael, Ferdinand, Vidic, Evra
Valencia, Giggs, Carrick, Young
Zabaleta, Kompany, Nastasic, Clichy
Milner, Tevez, Silva
Sir Alex Ferguson is still without Darren Fletcher, who is out for the season, but full back Rafael is expected to return from a groin injury.
However, there could still be a place for Phil Jones or Chris Smalling at right back, though the experienced pairing of Rio Ferdinand and Nemanja Vidic are expected to start at center back.
Up front, Ferguson's wealth of options means Chicharito, Danny Welbeck or Shinji Kagawa could be in contention to start ahead of Wayne Rooney or Robin van Persie.
The visitors, meanwhile, are still without injured full back Maicon (knee) but could welcome Micah Richards (knee) and Jack Rodwell (hamstring) back in time for Monday's clash.
Out-of-favor defender Joleon Lescott is likely to continue on the bench for Roberto Mancini's men, though City's top scorer in the Premier League, Edin Dzeko, could be in contention for a starting place.
|DID YOU KNOW?|
- Manchester United is on course for a record 21st domestic title. City pipped the Red Devils to the post last year, winning its first title in 44 years, but United now looks set to regain the trophy with a 15-point lead.
- The Red Devils can do the double over City with victory on Monday after a 3-2 win at the Etihad Stadium earlier in the season.
- Robin van Persie (pictured right) is Manchester United's top scorer with 23 goals in all competitions this season, but he has not netted in his last nine games for the club.
- Sir Alex Ferguson's men have not finished outside of the top three since 1991. They have also finished at least second in their last eight consecutive league campaigns.
- Manchester City has won its last seven games in all competitions and is unbeaten in 14 matches -- a run that has lasted since Boxing Day, when it lost 1-0 at Sunderland.
- City has scored 15 fewer goals than United this season, subsequently making its goal difference weaker than that of its cross-city rivals by 10.
- Away form has been the biggest problem for Mancini's men, with City suffering three defeats and five draws on the road. In stark contrast, the Premier League champions have only lost once and drawn three times at the Etihad, amassing 11 wins.
- Manchester City has beaten the Red Devils 16 times at Old Trafford in the teams' history, though it has lost to United 36 times at the same ground.