A group of fans have arranged for a plane with the message "Wrong One - Moyes Out" to be flown over Old Trafford during Saturday's fixture.
The televised Premier League clash at Old Trafford is likely to be overshadowed by events off the pitch — or rather in the air — as a section of the club's supporters look set to call for the under-fire Scot to be removed.
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And the ex-Everton boss could be in for an uncomfortable afternoon against Villa as a plane brandishing the message "Wrong One - Moyes Out" — a reference to "The Chosen One" banner at Old Trafford — will be flown over the stadium after being funded by a group of angry fans.
On the pitch, seventh-place United will attempt to restore some pride and put an end to a three-game winless streak on home soil in the Premier League.
The return of club captain Nemanja Vidic from a two-game ban is a timely boost, as is the fact that the crestfallen defending champions have an excellent record against Villa.
United has won the last six games between the two clubs and is unbeaten in nine encounters in all competitions.
The 3-0 victory at Villa Park back in December provided a rare highlight in an otherwise turbulent first season in charge for Moyes, who is still without Robin van Persie (knee).
With United facing Bayern Munich in the first leg of their Champions League quarterfinal tie Tuesday, Wayne Rooney has issued a rallying call to his teammates to move on from the Liverpool and City setbacks.
"We've got two big games coming up against Bayern Munich, but first we have to focus on the Villa game and try to end the season on a positive note," said the striker, who scored a spectacular long-range strike in the 2-0 win at West Ham last weekend.
Villa heads to Old Trafford striving to be the 10th team to leave with a point or more in the Premier League this season.
And while the 1-0 win over leader Chelsea earlier this month and 2-2 draw at Liverpool in January show that Paul Lambert's men are capable of more than holding their own in big games, Villa was ruthlessly beaten 4-1 by Stoke City last weekend to ground the club's players.
Lambert will nevertheless be targeting a top-half finish, with his side comfortably clear of relegation trouble. Karim El Ahmadi (thigh strain) and Andreas Weimann (dead leg) are both doubts after being withdrawn in the first half against Stoke.
Despite a disappointing display against Stoke, midfielder Marc Albrighton is confident of troubling United.
"If we can go to Old Trafford, put in a performance and get a result, everyone will forget about Sunday," he said.