Marcos Lopes was in the team that beat the Championship side in the third round last season and could be given another chance to start against it this weekend.
Lopes was aged just 17 years and eight days at the time and is hoping to get another opportunity to enhance his reputation in round four of this season's competition when City hosts the same opponent on Saturday.
The City starlet impressed in a 3-0 Capital One Cup semifinal second leg win at West Ham on Tuesday after being given the opportunity to start by manager Manuel Pellegrini.
Lopes is eager to catch the eye once again this weekend, as free-scoring City attempts to stretch its unbeaten run to 19 games in all competitions.
City is still in the hunt to win four trophies this season and has been in ominous form, winning 16 and drawing two of the last 18 matches.
Alvaro Negredo is not expected to be risked against Watford after injuring his shoulder at Upton Park in midweek, so Edin Dzeko could return to the starting lineup.
Pellegrini is also expected to ring the changes again, with Stevan Jovetic hoping to make his first start since October for a City side that has scored an incredible 68 goals in 17 home games this term.
Watford has not won away from home since October and faces a daunting task at the Etihad Stadium.
Giuseppe Sannino's side is 15th in the second tier and will be without defender Fitz Hall due to suspension.
Midfielder Alexander Merkel completes his three-match ban, while Tommie Hoban and Essaid Belkalem (both ankle) are set to miss out once again along with fellow defender Marco Cassetti (knee).