Andre Villas-Boas' men, who have scored just nine times in the Premier League this season, face a side which has won all five of its home games so far this season
The Etihad Stadium has become a fortress for Manuel Pellegrini this term, with 20 goals having been scored in City's five consecutive Premier League victories.
Spurs, in contrast, have scored just nine times in the league so far and lost their most recent game at home against Newcastle United.
However, Andre Villas-Boas' side has kept clean sheets in all but one of its nine matches in all competitions on the road this term.
Pellegrini saw his side lose to Sunderland before the international break, but remains confident of staying in touch with the teams at the top of the table.
"It is a tough match," he said. "I think they are a very good team.
"They have good players and play very good football. If we want to continue winning at home we need to play a very good game.
"I think it is a special Premier League this year. There are six or seven teams within four or five points. We will see what happens in the future.
"Finally, the team that plays the better football is the team that wins the league. We will see which of the six or seven teams will continue from now until the end of the season."
Pellegrini has injury worries to two of his star players - captain Vincent Kompany (thigh) and David Silva (calf) are both out of this match, while Stevan Jovetic (calf) also continues to be absent.
Christian Eriksen and Danny Rose (both ankle) are Tottenham's only injury worries ahead of the match, with a host of players returning for Villas-Boas.