Roberto Mancini's men will look to hit the ground running in their defense of the title against the newly-promoted Saints, who finished as runners-up in the second tier.
Zabaleta, Kompany, Lescott, Clichy
Yaya Toure, De Jong
Silva, Tevez, Nasri
Clyne, Fonte, Hooiveld, Fox
Guly, Schneiderlin, S Davis, Lallana
Click here to watch match live on FOX Soccer 2Go
Manchester City starts its first Premier League season as champion but could have both Joe Hart and Mario Balotelli out injured, with the duo missing the international friendly between England and Italy midweek. Hart could return after a back injury but Costel Pantilimon is ready to deputize, while Balotelli is less likely to feature after conjunctivitis.
Gareth Barry and Micah Richards will not play due to respective hernia and foot injuries but City's strength in depth will allow it to field a strong XI nevertheless.
Southampton starts its first Premier League campaign since its relegation with a first meeting between the pair in the higher echelons in five years.
Jack Cork will not feature after sustaining an ankle injury in the club's final preseason friendly but Nigel Adkins looks set to hand competitive team debuts to Nathaniel Clyne, Steven Davis and Jay Rodriguez, who signed from Crystal Palace, Rangers and Burnley respectively.
The Saints are in discussions with Gaston Ramirez, of Bologna, but will not complete the deal in time for him to feature.
|DID YOU KNOW?|
- Manchester City dropped just two points at the Etihad Stadium last season.
- It is on a run of 29 Premier League home games undefeated, with 27 of those wins.
- It is a clash of the goalscoring titans. City top scored in the Premier League with 93 goals; Nigel Adkins' (right) men scored the most in the Championship with 85.
- Southampton could struggle to win this match on the basis that only one newly promoted side - Blackpool - has won its opening game in the last three seasons.
- However, the last 16 Premier League fixtures between these two has seen the away side victors on seven occasions, while the home side have won only four.
- The last match between the pair in the top flight was five years ago.