City lost 3-2 to Norwich at the Etihad Stadium on the final day of last season, but the visitors could be without the likes of Ricky van Wolfswinkel and Nathan Redmon.
Manchester City will aim to recover its league form against Norwich City in a fixture that has produced 25 goals the last two seasons.
Manuel Pellegrini's men sit six points off the pace in the Premier League as they seek to regain the title they won in 2011-12. Sunday's defeat against Chelsea was City's third of their league campaign, although it did bounce back with a 2-0 League Cup win over Newcastle United on Wednesday.
City now takes on a Norwich side struggling in the relegation zone after three games without a league win. The onus will likely be on striker Sergio Aguero to deliver the goals, with the Argentina international having scored seven times this season, and four times in as many games against Norwich.
Still, Norwich did take all three points from the Etihad Stadium on the final day of last season, winning 3-2, gaining revenge after City had taken a 4-3 victory in another thrilling encounter at Carrow Road the previous December.
Chris Hughton's men will have hope of causing the opposition defense problems Saturday, with City captain and center back Vincent Kompany still on the sidelines because of a thigh injury. Attacking midfielder Stevan Jovetic also is a doubt after limping off in the victory against Newcastle.
Norwich's injury problems are far more severe as winger Nathan Redmond (thigh) and striker Ricky van Wolfswinkel (ankle) are doubts. Midfielder Robert Snodgrass is unlikely to play after sustaining a serious head injury in a 4-0 League Cup loss to Manchester United on Tuesday, while Elliot Bennett (knee) and Alexander Tettey (ankle) are unavailable.
But, despite a high number of prospective absentees, manager Hughton is hopeful of replicating the result his side achieved in May.
"It was a really good occasion and a great performance and result," he said. "You're always looking for pluses and ways in which the team can be motivated. We know our performances haven't been bad, but we haven't had the points to go with our performances. That's the reality.
"Nobody will deny that it's a tough ask but you've got to go there and be delighted by the challenge, and you've got to be excited by it too."