Roberto Martinez's men are yet to taste defeat in the Premier League and have a good record against the hosts, who will be hoping to improve after two defeats in a week.
The visitors have won nine of the past 12 league meetings between the two, with City triumphant just twice during that time. The Etihad has been a happy hunting ground for Everton of late, too, with the club securing three wins and a draw from its last five visits to the ground.
Everton will make the journey this term in good spirits, with genuine hopes of adding to their recent run. City, though, under new manager Manuel Pellegrini, has had a mixed start to the season so far, winning three, drawing one and losing two of its opening six league matches.
The most recent league outing ended in a surprise 3-2 defeat at Aston Villa, while on Wednesday the club was comprehensively beaten 3-1 at home by Bayern Munich in the Champions League.
The Citizens are the Premier League's top scorers this season with 14 so far, but they have been susceptible to conceding soft goals and currently sit seventh in the table, five points adrift of leaders Arsenal.
Pellegrini's side has lost a league-high number of points from winning positions (six), a figure that is in stark contrast to last season, when it dropped just seven points from winning positions across the entire campaign; however, it will take comfort from the fact that it has found the net in 53 successive home Premier League games in a run going back to November 2010.
Like City, Everton is also under new management this season, with Roberto Martinez coming in to replace the departed David Moyes. His new side has started strongly, boasting the only unbeaten record in the league thus far.
After three draws from the opening three league games, Martinez's side has won its last three games to climb to fourth in the table, three points behind Arsenal. Should Everton win on Saturday, it would represent the first time the club has won four successive league games since March 2008.
Everton's latest victory came in Monday's 3-2 win over Newcastle United at Goodison Park, with on-loan Chelsea striker Romelu Lukaku scoring two goals, on either side of a Ross Barkley strike.
That brace took Lukaku to three league goals for the season, and in his last six Premier League appearances the Belgium international has averaged a goal every 37 minutes he has been on the pitch.
Everton will be without England international midfielder Gareth Barry, as the terms of his season-long loan deal from City dictate that he is ineligible to face his parent club. Meanwhile, Martinez hopes Darron Gibson (knee) and Kevin Mirallas (ankle) will shake off their respective knocks in time to be included.
David Silva returned to action for City on Wednesday, but long-term absentee Martin Demichelis remains out with a knee injury, as does former Everton man Jack Rodwell with a muscle problem.