The Red Devils' win at Anfield last season followed four unsuccessful attempts, while new manager David Moyes never tasted victory there with his old Everton side
Brendan Rodgers's side has followed up its strong finish to last season by winning its opening two games of the new campaign against Stoke City and Aston Villa but, despite that good form, extending this sequence against its arch rival at Anfield will not be an easy task, as it has not beaten the Red Devils in their last four league meetings and lost the corresponding fixture 2-1 last season.
That victory was the first time that United had won at Liverpool in five attempts, though, and new boss David Moyes heads back to Merseyside looking for his first-ever victory at Anfield.
The Scot masterminded just three wins in 22 matches against Liverpool during his 11-year stint in charge of Everton - with all of those successes coming at Goodison Park.
Captain Steven Gerrard and in-form striker Daniel Sturridge are the men to whom the hosts will look to for inspiration in the absence of Luis Suarez, who serves the seventh game of his 10-match suspension.
Gerrard has scored four goals in his last six league appearances against United - including a goal in each of the last two encounters at Anfield - while Sturridge has netted 10 goals in his last eight appearances in all competitions.
Robin van Persie is likely to be the main threat for the visitors. The Dutchman, who has finished as the Premier League's leading goalscorer for the last two seasons, has netted four times in his last three top-flight appearances against Liverpool.
Rodgers will be without new signing Aly Cissokho as the 25-year-old is expected to be out for between four and six weeks after suffering an ankle injury during the Capital One Cup clash with Notts County.
However, close-season signing Kolo Toure, who also went off in Liverpool's second-round win over the League One outfit, could be fit after recovering well from a groin problem.
United has doubts over Rafael and Chicharito (both hamstring), while Portugal international Nani continues to struggle with a groin injury. Darren Fletcher is unavailable indefinitely due to a bowel condition.