Attentions turn back to the Premier League after both sides progressed to the FA Cup fifth round as Brendan Rodgers and Roberto Martinez chase a place in the top four.
Just a point separates fourth-placed Liverpool and its city rivals, who dropped down to sixth spot after they could only draw at West Brom in their last Premier League match.
There is little between the neighbors from across Stanley Park in the battle to secure Champions League football, and they have been evenly matched in recent encounters.
Both Liverpool manager Brendan Rodgers and Everton boss Roberto Martinez will be eager to secure their first Merseyside derby victory.
Rodgers' side has made a promising start to 2014, winning four of its five matches so far this year and reaching the fifth round of the FA Cup with a 2-0 win at Bournemouth on Saturday.
England striker Sturridge was on target against the Championship side and the former Chelsea man has now scored in each of his last four games.
Liverpool has made Anfield a fortress this season, losing only once at home when Southampton came away with a 1-0 victory back in September.
Rodgers is expected to recall in-form winger Raheem Sterling after the teenager started on the bench at Bournemouth, while Jon Flanagan is vying with Martin Kelly to start at right back in the absence of Glen Johnson, who was ruled out "indefinitely" by Rodgers in the week because of several injuries.
First-choice goalkeeper Simon Mignolet will return to the starting lineup after being rested on Saturday, but Lucas Leiva (knee), Jose Enrique (knee) and Daniel Agger (calf) all remain sidelined.
Joe Allen could be back after sitting out the trip to the south coast and it remains to be seen if Mamadou Sakho (hamstring) will be fit.
Everton also reached the fifth round of the FA Cup at the weekend, but its 4-0 win at Stevenage came at a cost as Bryan Oviedo suffered a double fracture of his left leg.
The Costa Rica international is set to miss the World Cup after sustaining the horrific injury against the League One strugglers and looks unlikely to play again for his club this season.
Everton has not won in the last seven derbies - a run stretching back to since October 2010 - but the trip to Anfield holds no fears for Martinez.
"I think we are capable of going anywhere and beating any team. What we will need on Tuesday night is a combination of those two games. We need to be absolutely perfect," he said. "We're not going to go to Anfield feeling inferior. We are not going there looking for a damage-limitation performance."
Martinez, whose side is unbeaten in its last six games, could include new signing Lacina Traore in his squad for the first time.
The Spaniard will check on the fitness of Seamus Coleman, who missed the trip to Stevenage with a minor soft tissue injury, and Steven Pienaar (groin).
Antolin Alcaraz (muscle fatigue) and Gerard Deulofeu (hamstring) could come back into contention, but Ross Barkley (broken toe), Darron Gibson and Arouna Kone (both knee) are definitely out.