Paul Lambert's beleaguered side, which boasts a surprisingly good away record, faces Brendan Rodgers' in-form Reds.
Brendan Rodgers' side has been dominant at Anfield this season, recording 10 victories from 11 matches in all competitions.
The Merseysiders host a Villa team that has claimed just one win in its last seven league outings.
Liverpool's resolute defense has formed a key part of its excellent home form, and no top-flight side can better the club's record of six goals conceded in league games in its own back yard.
But Villa has a solid record at Anfield in recent times, with just one loss in its last four visits, and claimed a 3-1 success on its last trip to Liverpool in Dec. 2012.
One of the visiting side's biggest challenges comes in the form of the Premier League's leading goalscorer, Luis Suarez, with the Uruguayan bagging 22 goals in 16 top-flight appearances thus far, 12 more than he registered in as many matches last season.
By contrast one of Villa's main attacking threats, Christian Benteke, has struggled to build on an impressive first season in English football, scoring just five times in the Premier League this term.
But the Belgium international will take heart from grabbing the consolation goal in Monday's 2-1 defeat to league leader Arsenal, a strike that ended a scoreless run of 11 top-flight matches for the 23-year-old.
Paul Lambert's charges occupy 11th position and will be buoyed by the fact that four of their six league wins have come away from home this campaign.
The home side welcomes back midfielder Joe Allen from an abductor problem, with center back Mamadou Sakho also in contention following a hamstring issue. Fullbacks Jon Flanagan (hamstring) and Jose Enrique (knee) remain sidelined, as do center backs Daniel Agger (calf) and Sebastian Coates (knee).
Villa could hand a debut to striker Grant Holt after he completed his loan signing from Wigan Athletic on Tuesday, but center back Nathan Baker is absent after sustaining a concussion against Arsenal.