Antonio Candreva opened the scoring from the penalty spot after Gianluigi Buffon had been dismissed for a professional foul, but the visitors' Spanish striker leveled mattersFernando Llorente was his team's savior as Juventus came from a goal down with 10 men to salvage a 1-1 draw at Lazio on Saturday evening.
The Serie A leaders - who had lost in the same stadium to Roma in the Coppa Italia on Tuesday - appeared to be heading for their first league defeat since October when Antonio Candreva notched from the penalty spot following the dismissal of Gianluigi Buffon, who brought down Miroslav Klose in the area.
But Llorente leveled proceedings in the second half to leave Lazio waiting for a first league triumph over Juventus since December 2003.
In a tight first half, Juve controlled possession but was hindered when keeper and captain Buffon was beaten to an intricate through ball by Klose, with Candreva keeping his cool to open the scoring from 12 yards.
The second half continued in a similar fashion, and the champions deservedly equalized when a well-worked move was finished by Llorente's fine header.
The draw ends Juve's 12-match winning league run, while Lazio has now won two and drawn two league matches since Edy Reja returned as coach earlier in January.
Lazio restored Hernanes to the starting XI after he scored a last-minute winner at Udinese last weekend, while Angelo Ogbonna moved to center back for the visitors with Giorgio Chiellini suspended.
The visitors started well but only had a speculative half-volley from Arturo Vidal after nine minutes to show for their early efforts.
At the other end, Lazio almost took the lead in bizarre circumstances when Klose caught Buffon in possession and the Germany international's challenge forced the ball just wide of goal.
Buffon's night went from bad to worse when he was shown a straight red card for denying a clear goalscoring opportunity after bringing down Klose in the area after 24 minutes.
From the resulting penalty, Candreva sent replacement goalkeeper Marco Storari the wrong way to break the deadlock.
Despite that setback, Juve continued to see plenty of the ball and it created a great opportunity nine minutes before halftime when Stephan Lichtsteiner's low center was collected by Llorente, who turned sharply in the box and forced a smart save from Etrit Berisha.
Juve showed no signs of suffering with its numerical disadvantage after the break, continuing to probe but struggling to orchestrate clear-cut chances.
Antonio Conte's charges showed their ruthlessness on the hour mark, however, as Llorente met Lichsteiner's pinpoint cross with a looping header to the far corner.
Buoyed by the leveler, Juve duly pushed for a winner and Carlos Tevez forced Berisha into a superb near-post save with a fierce strike.
However, with 15 minutes remaining, Storari produced a fine point-blank save to deny Klose's header from Cristian Ledesma's whipped free-kick.
A near carbon copy of that set-piece then led to Storari holding well from Klose's header, and the hosts kept up their late pressure when substitute Balde Keita curled an effort against the post in the 85th minute, but both sides were forced to settle for a point.