Roberto Mancini's side can retain second place with victory over the Danish giants and potentially go five points clear of Juventus.
Galatasaray could take a big step toward qualification for the Champions League knockout phase when it faces Copenhagen on Tuesday.
Roberto Mancini's men sit second in Group B following their 3-1 win over the Danish champions in the last round of fixtures last month. And the Turkish side travels to Scandinavia knowing that victory could move it five points clear of Juventus, which hosts group leader Real Madrid.
Strikers Umut Bulut and Didier Drogba should be key for Mancini's side, having each scored two goals in the competition so far. The duo will be confident of adding to their respective tallies against a Copenhagen side that has shipped eight goals and earned just one point in its first three group games.
However, Galatasaray has conceded one more goal than its counterpart, although the majority did come in the side's embarrassing 6-1 defeat to Real in the opening fixture.
The visitors are still without one of their main creative talents as midfielder Hamit Altintop misses out with a knee injury. Despite Hamit's absence, the Istanbul club possesses a plethora of attacking talent, with the likes of Wesley Sneijder and Burak Yilmaz also in their ranks.
Copenhagen - competing in the Champions League group stage for only the third time - is likely to be reliant on strikers Igor Vetokele and Nicolai Jorgensen if it is to earn its first win of this season's tournament. The players have netted 11 goals between them in all competitions so far, with Jorgensen scoring the opener in a surprise 1-1 draw with Juventus in September.
Stale Solbakken's men should take heart from that performance, and will hope that their forward line can help them to a similar result in front of their home fans at the Parken.
Thomas Delaney is the hosts' primary absentee, with the midfielder unable to take part due to suspension.