Antonio Conte's men leapfrogged Roma to go first in Serie A and can cling to the slender lead with a win over a side which has been inconsistent in 2013-14.
The reigning champion moved above Roma into top spot thanks to 2-0 victory at Livorno last weekend and will be confident of retaining that position against a club it is unbeaten against in four matches.
Francisco Guidolin's side has made an inconsistent start to the season, having failed to win back-to-back league games and losing four of its last six fixtures.
The club has also lost five of its six away Serie A matches this term, with the sole success coming in a 2-1 victory at newly promoted Sassuolo last month.
Goals have not been easy to come by for 11th-placed Udinese, as only the bottom two have scored fewer times than the team's total of 12.
To make matters worse for Guidolin, Colombian forward Luis Muriel - who has scored three of the team's 12 Serie A goals - will miss the trip to the Juventus Stadium with a thigh strain.
The home side comes into the game on the back of a morale-boosting win in the Champions League over Copenhagen, with Arturo Vidal scoring a hat trick in that game to take him to 10 goals in all competitions this season.
Carlos Tevez will also provide a threat to the Udinese defense, with the Argentina international having contributed 25 percent of Juventus' league goals this season with seven in 13 appearances since his move from Manchester City in the summer.
Conte will welcome back defenders Stephan Lichsteiner, Andrea Barzagli, and former Udinese man Mauricio Isla, but Sebastian Giovinco and Simone Pepe remain on the sidelines while Kwadwo Asamoah is suspended.