Saturday's visitor to Turin was the last team to win away to Antonio Conte's side in Serie A last January, but the Bianconeri are on an 11-game winning streak.
Juve slipped to a 2-1 home defeat to Samp in January last year, the visiting side coming from behind thanks to a double from Mauro Icardi to claim the points, despite being reduced to 10 men in the first half.
Samp went on to do the double over Antonio Conte's men with a 3-2 victory at Stadio Luigi Ferraris in May, but Juve has been utterly dominant in Turin since.
Only Bayern Munich has replicated Sampdoria's feat in the past year, the Bundesliga champion winning 2-0 at Juventus as the German giant marched to a Champions League title triumph.
Juve, which won 1-0 at Samp back in August, is likely to be the favorite to make it 12 Serie A wins in a row as Conte's side looks to further cement top spot and boost hopes of a third successive title.
However, Juve - eight points clear of nearest rival Roma - faces a Samp side that heads into the contest in form itself, having lost only one of its last seven league games.
That run has seen Sinisa Mihajlovic's men move clear of the relegation zone and the visiting side can jump into the top half of the table with another victory.
Samp striker Eder is wary of Juve, which has a fully-fit squad available for the game, but insists Mihajlovic's team is determined to cause an upset.
"We know that on Saturday we will come up against a great team," Eder told Tuttosport. "But currently Sampdoria has a different mindset to that of the past and for this we have to say thanks to Mihajlovic.
"We are not going sit back and defend, rather we will fight to bring home three points that are fundamental to our bid for survival."
Samp has no injury concerns, but will be without both Roberto Soriano and Nenad Krsticic due to suspension.