Pirlo, Vidal, Matri and Giovinco all scored to take full advantage of a shambolic defensive display from the visitors, with Osvaldo's penalty nothing more than bitter consolation
Fans at the Juventus Arena were in full voice long before kickoff, but they could never have predicted the start that their side would make to the match, as it raced into a three goal lead after 19 minutes.
Andrea Pirlo drilled home the opener in the 11th minute directly from a free-kick, before an Artuo Vidal penalty and a further goal from Alessandro Matri seemed to put the hosts out of sight against an overrun Roma side, which simply had no answer to wave after wave of attacks.
The Giallorossi would manage to claw their way back into contention during an improved second-half display, and a penalty from Osvaldo in the 69th minute gave the the faintest of hopes.
But there was nothing more to come from the visitors, who could not recover from their first-half fallacies as Sebastian Giovinco finished off a late counter-attack to send Juventus into a three point lead atop the table.
Matri was one of five changes for the Bianconeri from the 0-0 draw with Fiorentina, with Mirko Vucinic also handed a place in the starting XI in place of Fabio Quagliarella.
Meanwhile, Roma saw captain Daniele De Rossi return to the starting lineup after coming on as a substitute during the 1-1 draw with Sampdoria, while Mattia Destro was dropped in favor of Osvaldo.
There were already warning signs of things to come for Roma, as Claudio Marchisio came within inches of turning home a dangerous cross at the far post, moments before he was clumsily fouled on the edge of the box by Taddei, who was lucky to escape with a yellow card.
However, that would be the extent of the Brazilian’s fortunes, as his sloppy positioning in a wall allowed Pirlo to drill home a low free-kick into the corner from 20 yards out.
Five minutes later, a shambolic piece of defending on a cross forced Leandro Castan to concede a penalty in his attempts to clear the ball, from which Vidal stepped up to confidently bury the spot-kick.
Erik Lamela had an instant chance to reduce the arrears, but after ghosting in unmarked at the back post to meet a cross, he sidefooted wide from a few yards out.
Vidal would turn provider moments later, slipping in Matri past a collapsing Roma defense for a deflected finish beyond an unconvincing attempt to save by Maarten Stekelenburg.
Roma was awful in every area of the pitch, but its defending was especially shambolic as Juve had chance after chance to score again.
Stekelenburg spilled a routine shot that was almost pounced upon by Vucinic and seconds later, Marchisio smashed against the crossbar after breaking free yet again of the visitors’ backline.
The woodwork would come to Roma’s rescue once again, as Vucinic’s dipping shot from just inside the area cannoned off the top of the bar, after he was left completely unmarked.
The pattern seemed set to continue after the break, as a stinging drive from Vucinic seemed to be heading for the top corner, but for the fingertips of Stekelenburg.
However Juve, despite its continued dominance, did not display the cutthroat intensity of the opening period, as it seemed content to sit on a three-goal advantage.
That invited Roma back into the match, but the visitors, despite an improved display, were unable to penetrate the defense of the Bianconeri, who were only too happy to sit deep and break on the counter.
Roma was handed a lifeline in the 69th minute, after a careless barge by Leonardo Bonucci into Mattia Destro conceded a penalty, from which Osvaldo coolly sent Buffon the wrong way.
Osvaldo would nearly come up with the goods again, with a snap shot from inside the area that brought the very best out of Buffon, as the visitors looked to press forward in numbers late on.
However, time was not on Roma’s side, and Giovinco finished matters after rounding Stekelenburg on a late counterattack to put the icing on the cake of another Juventus victory in the new season.