Rudi Garcia's side is yet to taste anything other than victory in Serie A but faces a stern test against the resurgent Nerazzurri.
Rudi Garcia's side has won all six of its league outings so far this term, conceding just one goal in the process, but the hosts are also unbeaten. Walter Mazzarri has guided his men to four wins and two draws so far, a run that leaves them fourth in the table, four points behind the Giallorossi.
As well as boasting the league's stingiest defense, Roma is also the Italian top flight's leading scorer, with 17 goals. Roma's recent record in this fixture gives the visitors the edge, having won four and lost none of the last six meetings between the teams, an undefeated streak that includes two victories at San Siro last season.
Inter, though, followed up a commendable win over Fiorentina with a draw at Cagliari and goes into the weekend in good form. In stark contrast to their 2012-13 campaign, Inter has not been beset by injuries thus far this term, while seeing key players, such as forward Diego Milito, return from lengthy spells on the sidelines.
However, defender Christian Chivu (foot) is expected to miss another few weeks of action and club captain Javier Zanetti (Achilles tendon) could be out until December.
Garcia has a few more injuries with which to contend. Adem Ljajic (sciatic nerve) is doubtful, while Maicon (thigh), USA star Michael Bradley (ankle) and Mattia Destro (knee) will definitely not be involved.