Nerazzurri continue their superb run after coming back from a goal down to earn an important victory over the Biancocelesti in their bid to regain the Serie A title.
Goals from Diego Milito and Giampaolo Pazzini ensured the Nerazzurri extended their run of wins to eight in all competitions, despite Tommaso Rocchi putting the visitors in front early on, as Claudio Ranieri's men now leapfrog their opponent into fourth place in the table.
It was Inter which started most positively, mainly via the likes of Maicon surging down the right flank, but the club could have taken a lead in the most unlikeliest of circumstances. Federico Marchetti almost gifted Ricardo Alvarez the chance to break the deadlock from a poor clearance.
However, Lazio slowly crept back into the game, and the club was almost rewarded for its efforts through Rocchi, who was seemingly on hand to capitalize on Lucio's failure to read the ball and saw his poked attempt hit the post with Julio Cesar stranded.
Lazio eventually took the lead on 29 minutes, thanks to the visionary passing of Cristian Ledesma. He threaded Rocchi through one-on-one with the Brazilian goalkeeper and the striker latched onto the pass and dispatched his finish across the face of goal and into the corner.
However, despite overriding Biancocelesti pressure, Inter grabbed an equalizer on the edge of halftime. Ricardo Alvarez's one-two found Milito in the box, and the Argentine marksman struck coolly past Marchetti to restore parity before the interval.
There was potential for the stuffing to be knocked out of Lazio, as Inter looked to have gained the momentum, but the visiting side once again promptly set its stall out, looking to adopt a crisp passing style similar to that of the first half.
Inter, meanwhile, was keen to build on their momentum, and it paved the way for a pulsating second half. Minutes after the restart, Giampaolo Pazzini met Maicon's near-post cross, but Marchetti did well to block the striker's attempt.
And the persistence to go in front paid off, but not without some poor defensive play from Stefan Radu who allowed a lobbed pass from Lucio bounce over him. Pazzini was alert to anticipate the situation and chip the ball on the half volley over an onrushing Marchetti.
Inter switched to a 4-1-4-1 system and brought on Marco Faraoni for goalscorer Milito in order to see out the three points comfortably, but that did not deter Lazio from trying to flood balls into the Nerazzurri half, coinciding with the introduction of Abdoulay Konko.
Lazio remained in control of possession in the latter stages of the match, but the likes of Klose or Matuzalem failed to make their through balls count. The win sees Inter move within only six points of leader Juventus, while Lazio drops to fifth following the defeat.