Mark Hughes' side triumphed 3-2 over Chelsea at home last time out but the Potters have struggled on their travels, while the Tigers have lost just once in seven at the KC Stadium
Oussama Assaidi's stunning late goal earned a surprise victory over Jose Mourinho's men last time out - a result that extended Stoke's unbeaten Premier League run at the Britannia Stadium to five games.
But the club's home form is in stark contrast to its away-day troubles. Mark Hughes has seen his side go winless in five on the road, with the sole success on the road this term coming at West Ham back in August.
Hughes' team was thrashed 4-0 at Everton in its last away fixture but assistant manager Mark Bowen has urged the Midlanders to approach their trip to the KC Stadium in the same manner as their "huge" victory over Chelsea.
"It has given us even greater confidence and now we want to go to Hull at the weekend and replicate those performance levels," the Welshman told Stoke's official website.
However, Stoke will be well aware of the challenge awaiting the team at the KC Stadium, where newly-promoted Hull has lost just one of its seven top-flight matches this season.
Steve Bruce's side's only reverse on its own patch came at the hands of Crystal Palace last month, although the club bounced back superbly from that setback with a 3-1 win over Liverpool.
Hull's main problem this term has been in front of goal, as only bottom-placed Sunderland, Palace and Cardiff have scored fewer than the team's total of 13.
Robbie Brady is the club's top marksman with just three, although Bruce will be hopeful that on-loan Sunderland striker Danny Graham is buoyed by breaking his 30-game scoring drought in Monday’s 1-1 draw at Swansea City.
Hull has no new injury worries ahead of the clash, with Paul McShane and Stephen Quinn (both hamstring) and Sone Aluko (Achilles) the only absentees.
Stoke left back Erik Pieters is fit after missing the Chelsea win with a groin problem, although Jonathan Walters will miss out through suspension and Charlie Adam is doubtful due to a knock.
Robert Huth, meanwhile, remains sidelined after undergoing knee surgery.