With France and Switzerland firmly in control after opening victories, only three points can give either of these sides an outside chance of qualification.
Group E already seems clearly defined, with France and Switzerland well placed to qualify. It is up to Ecuador and Honduras to change that, but both are yet to taste victory at a World Cup.
Reinaldo Rueda's Ecuador side produced the more promising display in the first round of fixtures, with Enner Valencia putting the team ahead against the Swiss before goals from Admir Mehmedi and Haris Seferovic proved its undoing.
That Ecuador failed to get any points from that match despite being favored by the hot and humid conditions of Brasilia is a real worry, and anything less than a win here will see qualification hopes all but ended.
Honduras is in a worse situation, having been swept aside by France in an ill-tempered clash in Porto Alegre on Sunday which saw Wilson Palacios sent off.
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Karim Benzema put Luis Suarez's men to the sword and only the controversy caused by FIFA's goal-line technology system could deflect from the fact that the Central Americans were thoroughly outclassed.
One more defeat would see Honduras eliminated. In truth, the CONCACAF nation never expected to qualify - after failing to win a match in its two previous World Cup appearances, even a solitary win here would constitute real progress.
Ecuador is a deserved favorite after its spirited performance against the Swiss but Honduras has built its reputation on being a tough, uncompromising team. This will be a battle.