BVB is still without a number of key players at the back, including Mats Hummels, Neven Subotic and Sokratis, which could see youngster Marian Sarr feature in central defense.
Borussia Dortmund will look to end a poor run of Bundesliga form when the club visits mid-table Hoffenheim on Saturday.
Jurgen Klopp's men have lost three of their last four league matches and sit third in the table, 10 points behind Bayern Munich.
The team's last loss – a disappointing 1-0 defeat to second-placed Bayer Leverkusen – was compounded by ankle injuries suffered by Sven Bender and Nuri Sahin.
Sahin's problem was not serious and he returned to Dortmund's starting lineup for Wednesday's last-gasp 2-1 Champions League win over Marseille in France.
That win – which came courtesy of an 87th-minute winner from Kevin Grosskreutz – saw Dortmund finish on top of a tough Group F that also contained Arsenal and Napoli.
Without the goal Dortmund, last season's Champions League finalist, would have dropped out of the tournament and coach Klopp will hope the late win leads to a good run of form.
In Poland forward Robert Lewandowski, the club has the league's top scorer, with the 25-year-old having scored 11 in 15 Bundesliga matches this season.
Gabon forward Pierre-Emerick Aubameyang has added eight and could return to Dortmund's XI for this match, while defender Lukasz Piszczek is set to replace Erik Durm.
Manuel Friedrich – ineligible for the Champions League – suffered a toe injury and could be sidelined along with Sokratis Papastathopoulos who is suspended.
Marian Sarr, who was handed a Champions League debut in midweek, could continue in the starting XI at the back with either Grosskreutz or Koray Gunter as first-choice pairing Neven Subotic (knee) and Mats Hummels (ankle) are unavailable.
Dortmund has won five of its last six road trips, including a triumph at Premier League table-topper Arsenal, and the team will feel confident given Hoffenheim's dreadful home record, with Markus Gisdol's side having won only one of eight Bundesliga home fixtures this season.
The home side has won its last two matches, form which has seen the team rise to 11th, but its previous home success in the league came way back in September.
Attackers Roberto Firmino (eight goals) and Anthony Modeste (six goals) have been in form for Hoffenheim and only three sides have scored more goals, but no team has shipped more goals than Hoffenheim's 35. With Dortmund averaging two-and-a-half goals per match, the club will fancy its chances in attack.
Hoffenheim goalkeeper Jens Grahl made his debut last week and looks set to feature again for the home side.